Conditioned Compensatory Responses in rats to the Effects of
Caffeine on the Acoustic Startle Reflex in Olfactory Contexts
by Eric Sargent '02


Introduction
Methods
Results
Discussion
 

 

Abstract
 The purpose of this experiment was to establish olfactory stimuli as conditioned contexts capable of eliciting conditioned compensatory responses to the effects of caffeine. Previous research has shown that the pairing of a neutral stimulus with drug administration creates a classically conditioned relationship between the two. The originally unproductive stimulus now elicits certain responses opposite in effect to those of the drug. Past experiments in context conditioning have primarily utilized morphine, ethanol or various barbiturates; however, very little research has been done on caffeine in these scenarios. It was found that caffeine generally produced higher initial responses across all eight subjects during training sessions. This difference between the two decreased over the course of the session and was less noticeable in the final responses. Test data support the CCR model. Caffeine injections in different contexts elicited significantly higher responses than those injections received in familiar contexts.

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