Patrick Ouellette
Saint Anselm College

The Effects of Trimethyltim on working and
reference memory in the CF1 mouse


    The purpose of this experiment was to look at the effects of Trimethyltin on working and reference memory in the CF1 mouse. Trimethyltin, (TMT), is an organotin that has been found to have highly detrimental effects upon the the brain, specifically the hippocampus.  TMT is a neurotoxin that is used in many commercial as well as medical purposes.  These include the production of pesticides, herbicides, preservatives, and acne medication.  Cf1 mice were trained in two tasks, reference and working memory.  The reference memory task consisted of all mice finding a submerged platform from start position one.  Once criterion for this task was met the experimental group was administered TMT and a seven day recovery period was observed.  The mice then were placed at novel start location, start position two.  The performance was then assessed by comparing the control and experimental time to locate the platform location.  As hypothesized, the experimental group displayed an inability to locate the platform location from the novel start location.  This illustrated that working memory was impaired due to TMT.

Key Words: Trimethyltin, Working and Reference Memory, Hippocampus
Instrument: Morris Water Maze
Y.O.G. 1999

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